Dissolution/release and permeation – impact of bile

• In: Symposium B3: Lipid-Based and Lipid-Associated Drug Delivery - how to make lipophilic targets orally attractable on Tuesday, 23 May 2017, 15:45-16:20
• At: Stockholm (Sweden) (2017)
• Type: Presentation
• By: YAMASHITA, Shinji (Setsunan University, College of Pharmacy, Osaka, Japan)
• Co-author(s): Shinji Yamashita: College of Pharmacy, Setsunan University, Osaka, Japan
  
• Abstract:

  Food intake stimulates the secretion of bile and gives a great impact on the oral absorption of various drugs. Absorption of Class 2 drugs mostly undergoes positive food effect while that of Class 3 drugs does negative one. Since the current strategy of drug discovery often produces drug candidates with poor membrane permeability or poor

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