Surface adhesion of pharmaceutical powders in relation to tableting performance

• In: Short Communications C1 on Monday, 22 May 2017, 13:30-15:00
• At: Stockholm (Sweden) (2017)
• Type: Presentation
• By: BADAL TEJEDOR, Maria (SP, Stockholm, Sweden)
• Co-author(s): Maria Badal Tejedor: Chemistry, Materials and Surfaces, SP Technical Research Institute of Sweden, Stockholm, Sweden;Surface and Corrosion Science, KTH, Royal Intitute of Technology, Stockholm, Sweden
  Niklas Nordgren: Chemistry, Materials and Surfaces, SP Technical Research Institute of Sweden, Stockholm, Sweden
  Michael Schuleit: Novartis Intitutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland
  Anna Millqvist-Fureby: Chemistry, Materials and Surfaces, SP Technical Research Institute of Sweden, Stockholm, Sweden
  Mark Rutland: Surface and Corrosion Science, KTH, Royal Intitute of Technology, Stockholm, Sweden;Chemistry, Materials and Surfaces, SP Technical Research Institute of Sweden, Stockholm, Sweden
  
• Abstract:

  Backgrounds

  Problems associated to the adhesion of the powders to the tableting tools during tablet compaction are common. This is known as sticking and it remains poorly understood.

  Aims

  Analytical method development with atomic force microscopy (AFM) to characterize the mechanical and adhesive properties of the pharmaceutical powders.

  Methods

  ..

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