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Revisiting human tissue drug distribution: Limitations of current prediction models and potential impact of lipid contributions in fraction unbound
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-090-Monday
- By: MUSTHER, Helen (University of Manchester, Manchester, United Kingdom)
- Co-author(s): Helen Musther: Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom;, Simcyp Ltd (Certara), Sheffield, United Kingdom
Avijit Ghosh: Janssen Pharmaceuticals, PA, United States
Iain Gardner: Simcyp Ltd (Certara), Sheffield, United Kingdom
Amin Rostami-Hodjegan: Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom;, Simcyp Ltd (Certara), Sheffield, United Kingdom
David Hallifax: Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom - Abstract:
Backgrounds
Values of drug partitioning to tissue (Kp) are fundamental inputs to physiologically-based pharmacokinetic models. Since experimental determination in human presents practical and ethical challenges, models generally rely on predicted values. However, existing Kp prediction models have limitations which must be addressed to ensure their .. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
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Last update 28 September 2023