Development of a generic physiologically based pharmacokinetic model to predict drug target site concentrations in the CNS
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-111-Monday
- By: YAMAMOTO, Yumi (Leiden University, LACDR, Pharmacology, Leiden, Netherlands)
- Co-author(s): Yumi Yamamoto: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
Pyry A. Välitalo: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
Dirk-Jan van den Berg: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
Robin Hartman: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
Yin Cheong Wong: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
Dymphy R. Huntjens: Quantitative Sciences, Janssen Research & Development, Beerse, Belgium
Johannes H. Proost: Pharmacokinetics, Toxicology and Targeting, University of Groningen, Groningen, Netherlands
An Vermeulen: Quantitative Sciences, Janssen Research & Development, Beerse, Belgium
Walter Krauwinkel: Clinical Pharmacology & Exploratory Development, Astellas Pharma BV, Leiden, Netherlands
Meindert Danhof: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
Johan G. C. van Hasselt: Pharmacology, Leiden University, LACDR, Leiden, Netherlands
Elizabeth C. M. de Lange: Pharmacology, Leiden University, LACDR, Leiden, Netherlands - Abstract:
Backgrounds
Predicting human target site concentrations in the central nervous system (CNS) is challenging because of the presence of the blood-brain barrier and the blood-cerebrospinal fluid barrier. Furthermore, access to human brain samples is restricted because of practical and ethical reasons. A physiologically based pharmacokinetic (PBPK).. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
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Last update 28 September 2023