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P-glycoprotein neurotransmitters homeostasis modulation following the administration of CNS active drugs

  • At: Seville (Spain) (2022)
  • Type: Poster
  • Poster code: PPR-021
  • By: NICOLAE, Alina Crenguța (Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Romania)
  • Co-author(s): Prof. Alina Crenguța Nicolae (Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Bucharest, Romania)
    Carmen Adella Sirbu, Department of Neurology (Department of Neurology, Central Military Emergency University Hospital, 010242, Bucharest, Romania, Bucharest, Romania)
    Prof Cristina Manuela Dragoi, Associate Professor (Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Bucharest, Romania)
    Prof. Ion-Bogdan Dumitrescu (Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Bucharest, Romania)
  • Abstract:

    Background information
    The blood-brain barrier (BBB) restrains the pharmacotherapy of the majority of central nervous system (CNS) disorders, like brain cancer, epilepsy, and neurodegenerative diseases. A distinctive element of the BBB is the xenobiotics efflux transporter, P-glycoprotein (P-gp) which is a selective sentinel due to the high level..

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Last update 28 September 2023

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