Intestinal absorption of the prodrug Olmesartan Medoxomil is enhanced by oatp2b1-mediated uptake

• At: Seville (Spain) (2022)
• Type: Poster
• Poster code: DDD-010
• By: FUKAZAWA, Naomi (Keio University, Japan)
• Co-author(s): Ms Naomi Fukazawa, Faculty of Pharmacy (Keio University, Minato-ku, Japan)
  Dr Saki Noguchi (Keio University, Minato-ku, Japan)
  Dr Tomohiro Nishimura (Keio University, Minato-ku, Japan)
  Professor Masatoshi Tomi (Keio University, Minato-ku, Japan)
  
• Abstract:

  Background: Ester-prodrugs generally have a neutral charge at physiological pH and are orally absorbed via passive diffusion in the small intestine. Olmesartan medoxomil (OL-MX), an ester-prodrug of olmesartan (OL), is an oral approved-drug of angiotensin II receptor blockers (ARBs) and presents in the form of anions at intestinal pH. Organic..

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