DDM-007 - Enhanced solubility and membrane permeability by coamorphous nanoparticles via co-precipitation of two drugs

• At: Copenhagen (Denmark) (2025)
• Type: Poster
• Poster code: DDM-007
• By: UCHIYAMA, Hiromasa (Osaka Medical And Pharmaceutical University, Japan)
• Co-author(s): Dr Hiromasa Uchiyama (Osaka Medical And Pharmaceutical University, Takatsuki, Japan)
  Hiroto Kakuyama (Osaka Medical And Pharmaceutical University, Takatsuki, Japan)
  Yasuhiro Nomoto (Osaka Medical And Pharmaceutical University, Takatsuki, Japan)
  Dr Ryoma Tanaka (Osaka Medical And Pharmaceutical University, Takatsuki, Japan)
  Prof. Kazunori Kadota (Wakayama Medical University, Wakayama, Japan)
  Prof. Yuichi Tozuka (Osaka Medical And Pharmaceutical University, Takatsuki, Japan)
  
• Abstract:

  Introduction: Coamorphous solids represent an amorphous state in stoichiometric binary systems composed of a drug and a compatible coformer. The formation of coamorphous systems contributes to improving the solubility and oral absorption of target drugs. Typically, dry milling and spray drying are employed to produce coamorphous particles...

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