NMS-006 - Drug design and optimisation at the dihydroorotate dehydrogenase (DHODH) receptor using the teriflunomide scaffold as a lead

• At: Copenhagen (Denmark) (2025)
• Type: Poster
• Poster code: NMS-006
• By: SHOEMAKE, Claire
• Co-author(s): Ms Paula Zammit (University Of Malta, Msida, Malta)
  Dr Claire Shoemake (University Of Malta, Msida, Malta)
  
• Abstract:

  Introduction: Studies in mice show that dihydroorotate dehydrogenase (DHODH) inhibition is a novel route for the treatment of epilepsy. Given the fact that currently available pharmacotherapy produces only marginal control of the condition, DHODH inhibition has become important from a drug design perspective. Teriflunomide, used in multiple..

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