RSQ-021 - In-syringe polypropylene fiber-supported liquid-phase microextraction for determination of tyrosine kinase inhibitors by LC-MS

• At: Copenhagen (Denmark) (2025)
• Type: Poster
• Poster code: RSQ-021
• By: WANG, Dong (Tianjin Cancer Hospital Airport Hospital, China)
• Co-author(s): Prof Dong Wang (Tianjin Cancer Hospital Airport Hospital, Tianjin, China)
  Prof Chen Di (School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China)
  Mrs. Mengrong Li (Tianjin Cancer Hospital Airport Hospital, Tianjin, China)
  
• Abstract:

  Introduction:
  Tyrosine kinase inhibitors (TKIs) serve as targeted therapeutics for malignancies such as chronic myeloid leukemia and non-small cell lung cancer. However, their clinical application is challenged by narrow therapeutic windows, significant inter-individual metabolic variations, and potential hepatorenal toxicity. Therapeutic drug..

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