DDM-054 - Developing an innovative coamorphous salt formulation of telmisartan with amlodipine to enhance permeability and oral absorption

• At: Copenhagen (Denmark) (2025)
• Type: Poster
• Poster code: DDM-054
• By: TOZUKA, Yuichi (Osaka Medical And Pharmaceutical University, Japan)
• Co-author(s): Prof Yuichi Tozuka (Osaka Medical And Pharmaceutical University, Takatsuki, Osaka, Japan)
  Dr Yuta Hatanaka (Osaka Medical And Pharmaceutical University, Takatsuki, Osaka, Japan)
  Dr Ryoma Tanaka (Osaka Medical And Pharmaceutical University, Takatsuki, Osaka, Japan)
  Prof Kazunori Kadota (Wakayama Medical University, Wakayama, Japan)
  Dr Hiromasa Uchiyama (Osaka Medical And Pharmaceutical University, Takatsuki, Osaka, Japan)
  
• Abstract:

  Introduction: Coamorphous formulations represent a promising strategy for improving the solubility of poorly water-soluble drugs through intermolecular interactions. A hydrogen-bonding-based coamorphous system was developed to enhance drug solubility; however, it had little effect on the apparent permeability (Papp) of the drug. To overcome this..

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