NGPS-005 - Evaluation of copper-dependent enzymes activity in a murine model of Menkes disease.

• At: Copenhagen (Denmark) (2025)
• Type: Poster
• Poster code: NGPS-005
• By: YONEZAWA, Takuto (Faculty of Pharmacy, Musashino University, Japan)
• Co-author(s): Mr Takuto Yonezawa (Faculty of Pharmacy, Musashino University, Tokyo, Japan)
  Ms Mahiro Hirano (Faculty of Pharmacy, Musashino University, Tokyo, Japan)
  Ms Aiko Shimada (Faculty of Pharmacy, Musashino University, Tokyo, Japan)
  Ms Saya Matsuyoshi (Faculty of Pharmacy, Musashino University, Tokyo, Japan)
  Ms Yasuko Ogawa (Faculty of Pharmacy, Musashino University, Tokyo, Japan)
  Professor Ryo Suzuki (Faculty of Pharmacy, Teikyo University, Tokyo, Japan)
  Professor Hiroko Kodama (Faculty of Health and Medical Science, Teikyo Heisei University, Tokyo, Japan)
  Professor Hideyo Takahashi (Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan)
  Dr Yoshiaki Yamagishi (Faculty of Pharmacy, Musashino University, Tokyo, Japan / Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo, Japan)
  Dr Toshiyuki Kudo (Faculty of Pharmacy, Musashino University, Tokyo, Japan / Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo, Japan)
  Professor Kiyomi Ito (Faculty of Pharmacy, Musashino University, Tokyo, Japan / Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo, Japan)
  
• Abstract:

  Background: Menkes disease, a genetic disorder of the copper transport protein ATP7A, causes systemic copper deficiency. In patients, the activity of copper-dependent enzymes, including cytochrome ? oxidase (C?O), the last enzyme in the electron transport chain, and lysyl oxidase (LOX), an essential enzyme in connective tissue development, is..

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