DDM-018 - Modulation of P-glycoprotein expression and function in microglia: A drug barrier beyond the blood-brain barrier?

• At: Copenhagen (Denmark) (2025)
• Type: Poster
• Poster code: DDM-018
• By: KREUTZER, Ethan (Monash Institute of Pharmaceutical Sciences, Monash University, Australia)
• Co-author(s): Mr Ethan Kreutzer (Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia)
  Jennifer L Short (Monash Centre for Advanced mRNA Medicines Manufacturing & Workforce Training, Monash University, Clayton, Australia)
  Dorothy C C Wai (Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia)
  John K Fallon (Division of Pharmacoengineering & Molecular Pharmaceutics, University of North Carolina at Chapel Hill Eshelman School of Pharmacy, North Carolina, USA)
  Jacqueline B Tiley (Division of Pharmacotherapy & Experimental Therapeutics, University of North Carolina at Chapel Hill Eshelman School of Pharmacy, North Carolina, USA)
  Kim L R Brouwer (Division of Pharmacotherapy & Experimental Therapeutics, University of North Carolina at Chapel Hill Eshelman School of Pharmacy, North Carolina, USA)
  Joseph A Nicolazzo (Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia)
  
• Abstract:

  Background:
  Microglia, as the resident immune cells of the brain are involved in the initiation of inflammatory responses due to neurological disorders such as Alzheimer’s disease (AD). Microglia have functional drug transporters, including P-glycoprotein (P-gp), which can be compromised functionally due to the inflammatory activation of these..

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