DDM-016 - Enhancement of alpha-lipoic acid solubility through cyclodextrin ternary complexation for improved therapeutic efficacy

• At: Copenhagen (Denmark) (2025)
• Type: Poster
• Poster code: DDM-016
• By: MILJAK, Karolina
• Co-author(s): Ms Kristina Radić (University Of Zagreb, Faculty Of Pharmacy And Biochemistry, Zagreb, Croatia)
  Karolina Miljak (University Of Zagreb, Faculty Of Pharmacy And Biochemistry, Zagreb, Croatia)
  PhD Mario Jug (University Of Zagreb, Faculty Of Pharmacy And Biochemistry, Zagreb, Croatia)
  PhD Dubravka Vitali Čepo (University Of Zagreb, Faculty Of Pharmacy And Biochemistry, Zagreb, Croatia)
  
• Abstract:

  Alpha-lipoic acid (ALA) holds considerable therapeutic promise for treating obesity and its associated comorbidities, such as diabetic neuropathy and hyperlipidemia. However, achieving effective therapeutic doses requires high daily amounts (up to 1800 mg) due to ALA's poor bioavailability, which results primarily from its low solubility and..

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