PPM-020 - Application of popPK models for assessment of adherence to CDK4/6 inhibitor ribociclib

• At: Copenhagen (Denmark) (2025)
• Type: Poster
• Poster code: PPM-020
• By: SERTIC, Miranda
• Co-author(s): Lu Turković (University of Zagreb Faculty of Pharmacy and Biochemistry, Zagreb, Croatia)
  Prof. Iztok Grabnar (University of Ljubljana Faculty of Pharmacy, Ljubljana, Slovenia)
  Matea Baković (PrimeVigilance d.o.o., Zagreb, Croatia)
  Mojca Kerec Kos (University of Ljubljana Faculty of Pharmacy, Ljubljana, Slovenia)
  Maja Ortner Hadžiabdić (University of Zagreb Faculty of Pharmacy and Biochemistry, Zagreb, Croatia)
  Tajana Silovski (University Hospital Centre Zagreb, Zagreb, Croatia)
  Marija Križić (University Hospital Centre Zagreb, Zagreb, Croatia)
  Natalija Dedić Plavetić (University Hospital Centre Zagreb, Zagreb, Croatia)
  Prof Miranda Sertic (University of Zagreb Faculty of Pharmacy and Biochemistry, Zagreb, Croatia)
  
• Abstract:

  Introduction
  Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors, such as ribociclib, have revolutionized the treatment of HR+/HER2- advanced breast cancer. However, patient adherence to these therapies plays a crucial role in their efficacy, influencing clinical outcomes and overall survival. Population pharmacokinetic (popPK) models provide a..

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