DDM-036 - Evaluating the efficacy of valproic acid-loaded lipid nanoparticles for nose-to-brain delivery using a 3D-printed nasal cast

• At: Copenhagen (Denmark) (2025)
• Type: Poster
• Poster code: DDM-036
• By: SILVA, Ana (UCIBIO, Faculty of Pharmacy, University of Porto, Portugal)
• Co-author(s): Prof Ana Silva (UCIBIO, Faculty of Pharmacy, University of Porto, Porto, Portugal / Associate Laboratory i4HB Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Porto, Portugal / FP-I3ID (Instituto de Investigação, Inovação e Desenvolvimento), FP-BHS (Biomedical and Health Sciences Research Unit), Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal / Northern Regional Section of the Order of Pharmacists, Porto, Portugal)
  Carmo Correia (UCIBIO, Faculty of Pharmacy, University of Porto, Porto, Portugal / Associate Laboratory i4HB Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Porto, Portugal)
  Gonçalo Farias (Aptar Pharma, Le Vaudreuil, France)
  João Nuno Moreira (Center for Neuroscience and Cell Biology, Center for Innovative Biomedicine and Biotechnology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal / CNC - Center for Neuroscience and Cell Biology, Center for Innovative Biomedicine and Biotechnology (CIBB), Faculty of Medicine (Pólo I), University of Coimbra, Coimbra, Portugal)
  José Sousa Lobo (UCIBIO, Faculty of Pharmacy, University of Porto, Porto, Portugal / Associate Laboratory i4HB Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Porto, Portugal)
  
• Abstract:

  Introduction: Nose-to-brain (N2B) transport primarily occurs in the olfactory region, where drugs can reach the brain directly via the olfactory nerves. Therefore, maximizing olfactory deposition (OD) is crucial for effective N2B delivery. In this study, we evaluated the effectiveness of valproic acid-loaded nanostructured lipid carriers..

The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress. Please login