NMS-021 - Anti-neuroinflammatory effects and mechanism of exosome-like nanoparticles derived from Atractylodes lancea rhizome

• At: Copenhagen (Denmark) (2025)
• Type: Poster
• Poster code: NMS-021
• By: KAWADA, Kei (Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Japan)
• Co-author(s): PhD Kei Kawada (Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan / Department of Pharmacy, Tokushima University Hospital,, Tokushima, Japan)
  Tomoaki Ishida (Department of of Clinical Pharmacy Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan)
  Mizusa Hyodo (Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan)
  Yuki Izawa Ishizawa (Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan / Department of General Medicine, Taoka Hospital, Tokushima, Japan)
  Fuka Aizawa (Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan / Department of Pharmacy, Tokushima University Hospital,, Tokushima, Japan)
  Kenta Yagi (Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan / Clinical Research Center for Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan)
  Takahiro Niimura (Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan / Clinical Research Center for Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan)
  Mitsuhiro Goda (Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan / Department of Pharmacy, Tokushima University Hospital,, Tokushima, Japan)
  Keisuke Ishizawa (Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan / Department of Pharmacy, Tokushima University Hospital,, Tokushima, Japan / Clinical Research Center for Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan)
  
• Abstract:

  Background:
  Exosome-like nanoparticles (ELNs) mediate interspecific intercellular communication and regulate gene expression. ELNs derived from Atractylodes lancea rhizome (ALR-ELNs), a traditional herbal medicine, exhibit potential anti-neuroinflammatory effects on microglia. However, the mechanisms and associated signaling pathways remain..

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