Preparation and in vivo efficacy of insulin-containing enteric microspheres

• In: Pharmaceutical Biotechnology Posters
• At: Lisbon (Portugal) (2010)
• Type: Poster
• Poster code: PB-P-017
• By: CHANG, Li-Chien (National Defense Medical Center, Taipei, China Taiwan)
• Co-author(s): Chio, Yi-Chen (National Defense Medical Center, TAIPEI, China Taiwan)
  Chua, Anna Chian New (National Defense Medical Center, TAIPEI, China Taiwan)
  
• Abstract:

  Purpose: This work is to evaluate the feasibility of combining cell-penetrating peptide (CPP) and enteric coating strategies for oral insulin delivery. Methods: The CPP-modified insulin was synthesized by covalent linkage of a cell-penetrating peptide-low molecular weight protamine (LMWP) with insulin. Insulin and the modified insulin were..

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