Effect of pharmaceutical excipients on the stability of trichlormethiazide in tablets

• In: Industrial Pharmacy - Posters
• At: Basel (Switzerland) (2008)
• Type: Poster
• Poster code: IPS-P-057
• By: TERAOKA, Reiko (Kobe Pharmaceutical University, Kobe, Japan)
• Co-author(s): Matsushima, Yuki (Kobe Pharmaceutical University, KOBE, Japan)
  Sugimoto, Isao (Kobe Pharmaceutical University, KOBE, Japan)
  Inoue, Kana (Kobe Pharmaceutical University, KOBE, Japan)
  Kato, Fumie (Kobe Pharmaceutical University, KOBE, Japan)
  Morita, Shinya (Kobe Pharmaceutical University, KOBE, Japan)
  Kitagawa, Syuji (Kobe Pharmaceutical University, KOBE, Japan)
  
• Abstract:

  Purpose: It is known that many drug in the solid state undergo chemical change in the presence of some excipients. Trichlormethiazide is used as a potent diuretic drug and the drug is known to be hydrolyzed in aqueous solution and gelatin gels1, 2). The ten products were commercially available containing the brand product in Japan and various..

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