Influence of methylprednisolone pulse treatment on the pharmacokinetics of cyclosporine in rats.

• In: SIG Bioavailability/Bioequivalence Posters
• At: New Orleans (USA) (2004)
• Type: Poster
• Poster code: BB-P010
• By: KONISHI, Hiroki (Shiga University of Medical Science, Hospital Pharmacy, Otsu, Japan)
• Co-author(s): Sumi (Shiga University of Medical Science, OTSU, Japan)
  Morii (Shiga University of Medical Science, OTSU, Japan)
  Shibata (Kyoto Pharmaceutical Univ., Japan)
  Takada (Kyoto Pharmaceutical Univ., Japan)
  Minouchi (Shiga University of Medical Science, OTSU, Japan)
  Yamaji (Shiga University of Medical Science, OTSU, Japan)
  
• Abstract:

  We examined the effects of high-dose methylprednisolone (MP) on the pharmacokinetics of cyclosporin (CyA) in rats. To emulate the clinical protocol of MP pulse therapy, methylprednisolone sodium succinate (MPS) was intravenously administered as repeated doses (66.3 mg/kg/d) for 3 days. The total clearance of CyA was significantly decreased by..

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