Delvelopment of flurbifrofen-loaded solid dispersion with surface attached method

• In: Industrial Pharmacy - Posters
• At: Basel (Switzerland) (2008)
• Type: Poster
• Poster code: IPS-P-032
• By: YONG, Chul Soon (College of Pharmacy, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do, South-Korea)
• Co-author(s): Oh, Dong Hoon (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  Lee, Jong Suk (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  Lee, Won Seok (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  Woo, Jong Soo (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  Rhee, Jong-Dal (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  Li, Dong Xun (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  Yoo, Bong Kyu (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  Choi, Han-Gon (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, GYEONGSANGBUK-DO, South-Korea)
  
• Abstract:

  To improve the solubility and bioavailability of poorly water-soluble flurbiprofen, flurbiprofen-loaded solid dispersion was developed using the spray-drying technique with water, sodium carboxylmethyl cellulose (Na-CMC), and polysorbate 80 (Tween 80). The effect of Na-CMC and Tween 80 on the aqueous solubility and dissolution rate of flurbiprofen ..

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