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Design, Synthesis and Testing of novel small molecule inhibitors of S-phase Kinase-Associated Protein 2

  • In: Poster Presentation
  • At: Stockholm (Sweden) (2017)
  • Type: Poster
  • Poster code: P-A-022-Monday
  • By: LIU, Ran (Belrose, Australia)
  • Co-author(s): Ran Liu: Faculty of Pharmacy, University of Sydney, Sydney, Australia
    Paul Groundwater: Faculty of Pharmacy, University of Sydney, Sydney, Australia
    David Hibbs: Faculty of Pharmacy, University of Sydney, Sydney, Australia
    Thomas Grewal: Faculty of Pharmacy, Universit
  • Abstract:

    Backgrounds

    S-Phase Kinase-associated Protein 2 (Skp2), an oncoprotein, is overexpressed in numerous human cancers and plays a critical role in cell cycle progression, senescence, cancer progression and metastasis, through promoting th

    Aims

    Our project aims to develop small molecules which inhibit the interaction of Skp2 and p27, a process which is

    ..

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Last update 28 September 2023

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