DNP-NMR reveals the interior of lipid nanoparticle/mRNA formulations

• In: Short Communications B1 on Monday, 22 May 2017, 13:30-15:00
• At: Stockholm (Sweden) (2017)
• Type: Presentation
• By: SCHANTZ, Staffan (AstraZeneca R&D, Pharmaceutical Technology&Development, Mölndal, Sweden)
• Co-author(s): Jasmine Viger-Gravel: EPFL Lausanne, Institute des Sciences et Ingenierie Chimiques, Lausanne, Switzerland
  Anna Schantz: Pharmaceutical Sciences, AstraZeneca R&D, Mölndal, Sweden
  Aaron Rossini: Department of Chemistry, Iowa State university, Iowa, United States
  Arthur Pinon: EPFL Lausanne, Institute des Sciences et Ingenierie Chimiques, Lausanne, Switzerland
  Staffan Schantz: Pharmaceutical Technology&Development, AstraZeneca R&D, Mölndal, Sweden
  Lyndon Emsley: EPFL Lausanne, Institute des Sciences et Ingenierie Chimiques, Lausanne, Switzerland
  
• Abstract:

  Backgrounds

  Much interest focus on the development of lipid nanoparticles (LNPs) for the delivery of ribonucleic acids, e.g. small interfering (siRNA) and messenger (mRNA). LNPs are complex entities self-assembled from multiple components of different natures and many questions remain regarding their structure. For example, it is not well

  ..

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