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The science and the development of no-addictive opioid receptor agonists

  • At: 2016 FIP Congress in Buenos Aires (Argentina)
  • Type: Presentation
  • By: NAGASE, Hiroshi (University of Tsukuba, WPI-IIIS, Nagase Laboratory, Tsukuba, Japan)
  • Co-author(s): Hiroshi Nagase:
  • Abstract:

     For the past three decades, considerable efforts have focused on the search for an opioid κappa-receptor ,selective agonist without the undesirable morphine-like side effects (e.g., respiratory depression, constipation, physical dependence, etc.). In 1982, U-50488H was discovered to be a highly selective κappa-agonist. Subsequently, most of the..

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Last update 13 May 2019

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