Absorption profiles and intestinal toxicological assessment of hydrochlorothiazide (HCT)

• In: Poster presentation
• At: Buenos Aires (Argentina) (2016)
• Type: Poster
• Poster code: POS-FDP-008
• By: LONGHI, Marcela (Universidad Nacional de Cordoba, Facultad de Ciencias Químicas, Córdoba, Argentina)
• Co-author(s): Renée Onnainty:Facultad de Ciencias Químicas,Universidad Nacional de Cordoba,Córdoba,Argentina|Esteban Schenfeld:Facultad de Ciencias Químicas,Universidad Nacional de Cordoba,Córdoba,Argentina|Juan Petiti:Facultad de Ciencias Médicas,Universidad Nacional de Cordoba,Córdoba,Argentina|Marcela Raquel Longhi:|Alicia Torres:Facultad de Ciencias Médicas,Universidad Nacional de Cordoba,Córdoba,Argentina|Mario Quevedo:Facultad de Ciencias Químicas,Universidad Nacional de Cordoba,Córdoba,Argentina|Gladys Granero:Facultad de Ciencias Químicas,Universidad Nacional de Cordoba,Córdoba,Argentina
  
• Abstract:

  HCT presents low bioavailability, with a large variation in this parameter, ranging from 60% to 80%, which is relatively dose proportional. This variable oral bioavailability may be attributed to its poor solubility and poor permeability. Based on these facts it was proposed to study intestinal absorption of the drug. In function of this oral..

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