The effect of process variables on the encapsulation efficiency and release characteristics of insulin-loaded plga microspheres prepared by modified oil/oil solvent evaporation method

• In: Industrial Pharmacy Section - Posters
• At: Beijing (China) (2007)
• Type: Poster
• Poster code: IPS-P-021
• By: HAMISHEHKAR, Hamed (Isfahan University of Medical Sciences, Isfahan, Iran)
• Co-author(s): Emami, Jaber (Isfahan University of Medical Sciences, ISFAHAN, Iran)
  Rouholamini, Abdolhossien (Tehran University of Medical Sciences, TEHRAN, Iran)
  Gilani, Kambiz (Tehran University of Medical Sciences, TEHRAN, Iran)
  Nokhodchi, Ali (The Universities of Kent and Greenwich, KENT, United Kingdom)
  Minaiyan, Mohsen (Isfahan University of Medical Sciences, ISFAHAN, Iran)
  Mahdavi, Hamid (Iran Polymer and Petrochemical Institute, TEHRAN, Iran)
  
• Abstract:

  To increase the encapsulation efficiency of water soluble drugs (protein and peptides) and to optimize the release characteristics of protein, an oil-in-oil (o/o) emulsification technique was developed. The impact of process variables including polymer concentration (1.6 and 3.2 %), polymer molecular weight (6 and 36 kDa), stirring speed (3000 and ..

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