Liver p450s play an important role in kidney toxicity induced by aristolochic acid

• In: SIG Natural Substances - Posters
• At: Beijing (China) (2007)
• Type: Poster
• Poster code: NS-P-068
• By: XIAO, Ying (Shanghai Institute of Materia Medica, Shanghai, China)
• Co-author(s): Gu, Jun (New York State Department of Health, ALBANY, United States of America)
  Zhu, Hongli (Shanghai TenGen Biomedical Company, SHANGHAI, China)
  Ren, Jin (Shanghai Institute of Materia Medica, SHANGHAI, China)
  
• Abstract:

  The xenobiotic-metabolizing P450s play an important role in the metabolism of endogenous and exogenous chemicals, including aristolochic acid (AA), a potential carcinogen and potent toxicant responsible for Aristolochic Acid Nephropathy (AAN). It has been known that AA is metabolized by certain isoforms of P450 in both liver and kidney microsomes. ..

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