Lovastatin protection from intestinal metabolism by oral lipid particles and bioavailability study

• In: SIG Bioavailability/Bioequivalence - Posters
• At: Beijing (China) (2007)
• Type: Poster
• Poster code: BB-P-015
• By: GAN, Yong (Shanghai Institute of Materia Medica, Shanghai, China)
• Co-author(s): Ge, Zhen (Shanghai Institute of Materia Medica, SHANGHAI, China)
  Zhang, Xinxin (Shenyang Pharmaceutical University, SHENYANG, China)
  Zhu, Chunliu (Shanghai Institute of Materia Medica, SHANGHAI, China)
  
• Abstract:

  OBJECTIVE To prepare lovastatin-loaded oral lipid particles drug delivery system and investigate protective effects from intestinal CYP3A4 metabolism and the influence of oral bioavailability. METHOD Phosal 53 MCTÂ[RSYMBOL] , Tween 80 and Starch Sodium Octenyl Succinatd were employed as oil phase, emulsifying agent and matrix material,..

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