DIVERSITY OF DRUG HYPERSENSITIVITY GENES WITH SPECIAL REFERENCE TO COLD MEDICINE-RELATED STEVENS-JOHNSON SYNDROME

• In: B1 - “Getting personal”: pharmacogenomics at the crossroads of practice and science on Thursday, 1 October 2015, 09:00-12:00
• At: Düsseldorf (Germany) (2015)
• Type: Presentation
• By: TOKUNAGA, Katsushi (Graduate School of Medicine, University of Tokyo, Department of Human Genetics, Tokyo, Japan)
• Co-author(s): Katsushi TOKUNAGA
  
• Abstract:

  We investigate a specific type of SJS/TEN, accompanied by eye manifestations and related to certain types of cold remedies.  Association with HLA-A*02:06 was found in Japanese and replicated in Korean.  In silico docking simulations predicted that the A0206 molecule has high binding affinities to various ingredients including ethenzamide and

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