Cleaning tumor margins via abrogation of heat shock protein 90 with protein engineered tri-block biopolymer-geldanamycin conjugates

• In: SUBMITTED ORALS on Tuesday, 15 April 2014, 13:00-14:30
• At: PSWC, Melbourne (Australia) (2014)
• Type: Presentation
• By: CHEN, Yizhe (University of Utah, Pharmaceutics and Pharmaceutical Chemistry, Salt lake city, United States of America)
• Co-author(s): Youn, Pilju (University of Utah, Salt lake city, United States of America)
  Furgeson, Darin (University of Utah, Salt lake city, United States of America)
  
• Abstract:

  I. Hepatocellular carcinoma (HCC) remains a lethal cancer with extremely low survival rates. First line clinical therapies, such as thermal ablation, suffer tumor recurrence rates near 40%. Incomplete ablation at tumor margins, poor drug formulation, and lack of drug targeting are suggested as major causes of poor clinical outcomes. Heat shock

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