Development of high efficient gene delivery system with anionic surface charge

• In: SIG Posters
• At: Amsterdam (the Netherlands) (2012)
• Type: Poster
• Poster code: BIO-P-06
• By: SASAKI, Hitoshi (Nagasaki University Hospital, Department of Hospital Pharmacy, Nagasaki, Japan)
• Co-author(s): Kurosaki, T. (Nagasaki University Hospital, Nagasaki, Japan)
  Kodama, Y. (Nagasaki University Hospital, Nagasaki, Japan)
  Higuchi, H. (Nagasaki University Hospital, Nagasaki, Japan)
  Kitahara, T. (Nagasaki University Hospital, Nagasaki, Japan)
  Nakamura, T. (Nagasaki University Hospital, Nagasaki, Japan)
  
• Abstract:

  We discovered a vector coated by gamma-polyglutamic acid (gamma-PGA) for effective and safe gene delivery. In order to develop a useful non-viral vector, we prepared several ternary complexes constructed with pDNA, polyethylenimine (PEI), and various polyanions, such as polyadenylic acid, polyinosinic-polycytidylic acid, alpha-polyaspartic acid,

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