Determination of piperphentonamine and metabolites M1 and M6 in human plasma and urine by LC/MS/MS and its application in a pharmacokinetics study in Chinese healthy volunteers

• In: SIG Posters
• At: Amsterdam (the Netherlands) (2012)
• Type: Poster
• Poster code: PAA-P-12
• By: SHI, Aixin (Beijing Hospital of Ministry of Health, Department of Pharmacy, Beijing, China)
• Co-author(s): Hu, H.X. (Beijing Hospital of Ministry of Health, Beijing, China)
  Li, L.K.X. (Beijing Hospital of Ministry of Health, Beijing, China)
  Wan, W.H.Y. (Huayin, Guangzhou, China)
  
• Abstract:

  Background: Piperphentonamine hydrochloride(PPTA) is a new calcium sensitizer.
  Aims: A simple and sensitive liquid chromatography-tandem mass spectrometry(LC/MS/MS) method for determination of piperphentonamine and its metabolites M1 and M6 was developed for the first time and applied to a pharmacokinetics study.
  Methods:Protein precipitation was

  ..

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