Pharmacogenetic association with adverse reactions to thiopurine drugs in japanese pediatric patients

• In: Hospital Pharmacy - Posters
• At: Istanbul (Turkey) (2009)
• Type: Poster
• Poster code: HPS-P-100
• By: NAORA, Kohji (Shimane University Hospital, Izumo, Japan)
• Co-author(s): Hara, Yukari (Shimane University Hospital, IZUMO, Japan)
  Nishimura, Nobuhiro (Shimane University Hospital, IZUMO, Japan)
  Taketani, Takeshi (Shimane University Hospital, IZUMO, Japan)
  Kanai, Rie (Shimane University Hospital, IZUMO, Japan)
  Yamaguchi, Seiji (Shimane University Hospital, IZUMO, Japan)
  Iwamoto, Kikuo (Aichi Gakuin University, NAGOYA, Japan)
  
• Abstract:

  Aims: Thiopurine drugs, 6-mercaptopurine (6-MP) and azathioprine (AZA), are used in chemotherapy against acute leukemia and for immunomodulation in autoimmune diseases. Adverse drug reactions to 6-MP or AZA often necessitate withdrawal of the therapy. In recent years, genetic polymorphisms in metabolic enzymes of thiopurines, inosine triphosphate..

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