Tacrolimus-josamycin interaction in a recipient of allogeneic bone marrow transplantation

• In: Hospital Pharmacy - Posters
• At: Istanbul (Turkey) (2009)
• Type: Poster
• Poster code: HPS-P-057
• By: NAKAMURA, Mai (Medical Center of Japan Toyama Hospital, Tokyo, Japan)
• Co-author(s): Mori, Tatsuya (Division of Pharmacy, International Medical Center of Japan Toyama Hospital, TOKYO, Japan)
  Sawai, Takao (Division of Pharmacy, International Medical Center of Japan Toyama Hospital, TOKYO, Japan)
  Atsuta, Kazuyoshi (Division of Pharmacy, International Medical Center of Japan Toyama Hospital, TOKYO, Japan)
  Yamanaka, Junko (Division of Pediatrics, International Medical Center of Japan Toyama Hospital, TOKYO, Japan)
  Okuma, Yosiaki (Division of Pediatrics, International Medical Center of Japan Toyama Hospital, TOKYO, Japan)
  Matsushita, Takeji (Division of Pediatrics, International Medical Center of Japan Toyama Hospital, TOKYO, Japan)
  Mikami, Jiro (Division of Pharmacy, International Medical Center of Japan Toyama Hospital, TOKYO, Japan)
  
• Abstract:

  Tacrolimus (FK506) is a potent macrolide immunosuppressive agent used for the prophylaxis and treatment of organ rejection and graft-versus-host disease (GVHD) after allogeneic organ or stem cell transplantation. The systemic clearance of FK506 is mainly explained by cytochrome P450 (CYP)3A4-mediated metabolism in the liver and small intestine...

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