Determination of creatinine, neopterin and its derivatives biopterin, dihydroneopterin and tetrahydroneopterin by uplc-ms/ms

• In: G20 - Short oral communications on Pharmaceutical Manufacturing and Drug Delivery Technologies on Wednesday, 3 September 2008, 9:00-11:49
• At: Basel (Switzerland) (2008)
• Type: Presentation
• By: NOVáKOVá, Lucie (Charles University, Faculty of Pharmacy, Hradec Králové, Czech Republic)
• Co-author(s): Solichová, Dagmar (Department of Metabolic Care and Gerontology, Teaching Hospital, Hradec Králové, Czech Republic)
  Melichar, Bohuslav (Department of Oncology, Palacký University Medical School & Teaching Hospital,, Czech Republic)
  Solich, Petr (Charles University, Faculty of Pharmacy, Hradec Králové, Czech Republic)
  
• Abstract:

  Creatinine is a major breakdown product of mammalian metabolism produced in muscle tissue and eliminated in urine. The urinary creatinine concentration is often used to correct urinary excretion of other chemical substances due to urine dilution effects, since the excretion of creatinine is reasonably constant throughout the day. Neopterin is

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