Development of Hydroxy-Based SphK Inhibitors and Anti-Inflammation in DSS Induced Colitis in Mice

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-051-Monday
• By: XI, Meiyang (Beijing, China)
• Co-author(s): Meiyang Xi: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  Xiaojian Wang: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  Qiong Xiao: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  Hui Wen: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  Xiang Zhang: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  Huaqing Cui: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  Dali Yin: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  
• Abstract:

  Backgrounds

  Sphingosine kinase (SphK)-catalyzed production of sphingosine-1-phosphate (S1P) regulates cell growth, survival and proliferation as well as inflammatory status in animals. 

  Aims

   to find an anti-inflammatory agent to probably treat inflammatory bowel diseases in human.

  Methods

  SAR  DSS induced mouse models 

  Results

   In recent study we
  ..

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