Stability evaluation of Amphotericin B-containing micellar systems after heating process

• In: Poster presentation
• At: Buenos Aires (Argentina) (2016)
• Type: Poster
• Poster code: POS-FDP-011
• By: SILVA, André (Universidade Federal Do Rio Grande Do Norte, Laboratório de Sistemas Dispersos, Natal, Brazil)
• Co-author(s): André Leandro Silva:Laboratório de Sistemas Dispersos,Universidade Federal Do Rio Grande Do Norte,Natal,Brazil;Institut Galien Paris-Sud,Université Paris-Sud,Châtenay-Malabry,France|Monique Chéron:Institut Galien Paris-Sud,Université Paris-Sud,Châtenay-Malabry,France|Gilles Ponchel:Institut Galien Paris-Sud,Université Paris-Sud,Châtenay-Malabry,France|Eryvaldo Egito:Laboratório de Sistemas Dispersos,Universidade Federal Do Rio Grande Do Norte,Natal,Brazil
  
• Abstract:

  Amphotericin B (AmB) is available in the market as a micellar-lyophilized system, which has to be used promptly after reconstitution due to its high degradation in aqueous medium.

  Three differente AmB-micellar systems were diluted in pure water at 5.10^-3 M AmB (5mg/mL).  AmB-containing liposome (AmBisome®) was also diluted at the same conditions.

  ..

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