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Construction of genetically- engineered strain to improve the geldanamycin production and its cultivation

  • In: SIG Pharmaceutical Biotechnology - Posters
  • At: Beijing (China) (2007)
  • Type: Poster
  • Poster code: PB-P-041
  • By: HE, Weiqing (Institute of Medicinal Biotechnology, Beijing, China)
  • Co-author(s): ZHOU, Hongxia (Institute of Medicinal Biotechnology, BEIJING, China)
    WANG, Hongyuan (Institute of Medicinal Biotechnology, BEIJING, China)
    Gao, Qunjie (Institute of Medicinal Biotechnology, BEIJING, China)
    WANG, Yiguang (Institute of Medicinal Biotechnology, BEIJING, China)
  • Abstract:

    OBJECTIVE To improve the fermentation production of the geldanamycin (Gdm) producer, S.hygroscopicus 17997 and to study the sporulation cycles on solid medium cultivation of the obtained strain. METHODS Gene disruption was carried by homologous DNA recombination to delete the genes (shnSOP) in another set of the gene cluster in the..

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Last update 28 September 2023

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