Improvement of the triene macrolide immunosuppressant, sirolimus, producing strain streptomyces hygroscopicus fc904

• In: SIG Natural Substances - Posters
• At: Beijing (China) (2007)
• Type: Poster
• Poster code: NS-P-064
• By: CHENG, Yang-rong (Fujian Institute of Microbiology, Fuzhou, China)
• Co-author(s): Huang, Jie (Fujian Institute of Microbiology, FUZHOU, China)
  Jin, Dong-wei (Fujian Institute of Microbiology, FUZHOU, China)
  Yu, Hui (Fujian Institute of Microbiology, FUZHOU, China)
  
• Abstract:

  Objective In an attempt to improve the productivity of sirolimus(SLM) producer Streptomyces hygroscopicus FC904. Method Mutation and screening of the starting culture, S. hygroscopicus FC904 were carried. Thousands of survivors were obtained after repeating mutagenis by UV and chemical mutagenic agents. Higher SLM-producing mutants were selected..

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