DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL SPIROISOXAZOLIN DERIVATIVES AS SELECTIVE COX-2 INHIBITORS

• In: Poster Session
• At: Düsseldorf (Germany) (2015)
• Type: Poster
• By: ABOLHASANI, Hoda (School of Medicine, Qom University of Medical Sciences, Qom, Iran, Departement of Pharmacology, Qom, Iran)
• Co-author(s): Hoda Abolhasani
  
• Abstract:

  Chronic inflammation may be a causative factor in a variety of cancers. Selective COX-2 inhibitors are used as anti-inflammatory agents and COX-2 over expression has been demonstrated in several cancers.

   

  New spiroisoxazoline derivatives were designed and synthesized for evaluation as selective COX-2 inhibitors by Cayman kit. Docking studies were

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