Population-based methods to guide dosage adjustments

• In: F3 - Personalized medicine: Pharmacokinetics and pharmacodynamics at the point-of-care on Monday, 1 September 2014, 9:00-12:00
• At: Bangkok (Thailand) (2014)
• Type: Presentation
• By: MASUDA, Satohiro (Kyushu University Hospital, Pharmacy, Fukuoka, Japan)
• Co-author(s): Matsubara, Kazuo (Kyoto University Hospital, Kyoto, Japan)
  Uemoto, Shinji (Kyoto University Hospital, Kyoto, Japan)
  
• Abstract:

  I. Background Because of a large inter-individual variation in the pharmacokinetics, individualized dosage regimens of tacrolimus and cyclosporine have not been established except for the TDM-based dosage modification. Recently, efflux pump P-glycoprotein (MDR1/ABCB1) and CYP3A4/5 in the intestine as well as the liver were identified to affect

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