Species difference in stereoselective oxidation of carvedilol enantiomers in rat and human
- At: PSWC, Melbourne (Australia) (2014)
- Type: Poster
- By: IWAKI, Masahiro (Kinki University, Department of Pharmacy, Higashi-osaka, Japan)
I. Background: The oxidation of carvedilol (CAR), β-adrenoceptor antagonist, is mediated by cytochrome P450 (CYP)2D6, with possible contributions by CYP1A2, CYP2C9, CYP2C19 and CYP3A4 in human.
II. Aims: As rats are an important tool in pharmacology and toxicology, we focus on the species difference in CYP isoforms responsible for the oxidation of .. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.