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Species difference in stereoselective oxidation of carvedilol enantiomers in rat and human

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: IWAKI, Masahiro (Kinki University, Department of Pharmacy, Higashi-osaka, Japan)
  • Abstract:

    I. Background: The oxidation of carvedilol (CAR), β-adrenoceptor antagonist, is mediated by cytochrome P450 (CYP)2D6, with possible contributions by CYP1A2, CYP2C9, CYP2C19 and CYP3A4 in human.
    II. Aims: As rats are an important tool in pharmacology and toxicology, we focus on the species difference in CYP isoforms responsible for the oxidation of ..

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Last update 4 October 2019

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