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Preventing the blood-brain barrier disruptive effects of lipopolysaccharide with polymyxin analogues

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: MCINERNEY, Mitchell (Monash University, Faculty of Pharmaceutical Sciences, Melbourne, Australia)
  • Co-author(s): Nicolazzo, Joseph (Monash University, Melbourne, Australia)
    Jin, Liang (Monash University, Melbourne, Australia)
    Nation, Roger (Monash University, Melbourne, Australia)
    Li, Jian (Monash University, Melbourne, Australia)
    Velkov, Tony (Monash University, Melbourne, Australia)
  • Abstract:

    Background information: The frequency of multidrug-resistant bacteria appearing in the clinic is increasing. These species release toxic molecules called lipopolysaccharides (LPS) which have the ability to cause tight junction disruption in the blood-brain barrier (BBB) and subsequent BBB hyper-permeabilisation. Previous studies have demonstrated..

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Last update 4 October 2019

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