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Physiologically based pharmacokinetic (pbpk) modeling for the prediction of drug-drug interactions mediated by hepatic uptake transporters, oatps

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: YOSHIKADO, Takashi (RIKEN, Sugiyama Laboratory, Yokohama, Japan)
  • Co-author(s): Yoshida, Kenta (The University of Tokyo, Tokyo, Japan)
    Maeda, Kazuya (The University of Tokyo, Tokyo, Japan)
    Sugiyama, Yuichi (RIKEN, Yokohama, Japan)
  • Abstract:

    [Purpose] A physiologically based pharmacokinetic (PBPK) model is useful for the quantitative prediction of drug-drug interaction (DDI), in which change in the concentration of an inhibitor over time is taken into account. The purpose of this study was to analyze DDI cases between statins and cyclosporine A primarily caused by the inhibition of..

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Last update 4 October 2019

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