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Inhibition of basolateral efflux transporter causes drug induced bile acids-dependent hepatotoxicity

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: SUSUKIDA, Takeshi (Graduate School of Pharmaceutical Sciences, Chiba University, Laboratory of Biopharmaceutics, Chiba, Japan)
  • Abstract:

    [Background and Aims] Bile salt export pump (BSEP) is localized on canalicular membrane of hepatocytes and plays a role of bile acids (BAs) efflux into bile. Dysfunction of BSEP may lead to cholestatic liver injury due to BAs accumulation in hepatocytes. We have constructed a method using sandwich cultured hepatocytes (SCHs) to evaluate..

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Last update 4 October 2019

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