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Modeling of rifampicin-induced cyp3a4 activation dynamics for the prediction of clinical drug-drug interactions

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: YOSHIDA, Shuya (Graduate School of Pharmaceutical Sciences, Kyoto University, Department of Drug Delivery Research, Kyoto, Japan)
  • Co-author(s): Sasa, Yukako (Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan)
    Yamashita, Fumiyoshi (Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan)
    Hashida, Mitsuru (Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan)
  • Abstract:

    Induction of drug metabolizing enzymes accelerates clearance of drugs from the body, resulting in attenuation of their therapeutic efficacy. Rifampicin is an agonist of pregnane X receptor (PXR) and strongly induces cytochrome P450 3A4 (CYP3A4). Therefore, many of drugs that are mainly metabolized by CYP3A4 are not compatible with rifampicin for..

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Last update 4 October 2019

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