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Optimizing the therapeutic activity of sphingosine-1-phosphate receptor modulators through lymph targeted delivery

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: CAO, Enyuan (Monash University, Pharmaceutics, Parkville, Australia)
  • Co-author(s): Trevaskis, Natalie (Monash University, Parkville, Australia)
    Hu, Luojuan (Monash University, Parkville, Australia)
    Christopolous, George (Monash University, Parkville, Australia)
    Aurelio, Luigi (Monash University, Parkville, Australia)
    Sexton, Patrick (Monash University, Parkville, Australia)
    Flynn, Bernard (Monash University, Parkville, Australia)
    Porter, Christopher (Monash University, Parkville, Australia)
  • Abstract:

    Background: Sphingosine-1-phosphate (S1P) receptor modulators (S1PRMs) show therapeutic effect in autoimmune disease by blocking lymphocyte egress from lymph nodes resulting in systemic lymphopenia. The S1PRM fingolimod is used clinically for multiple sclerosis but has significant off-target toxicities. Targeting S1PRM to their site of action..

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Last update 4 October 2019

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