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Cis/trans isomerism is an important determinant of clearance processes for two pairs of 1,2,4-trioxolanes.

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: MANNILA, Janne (Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Parkville, Australia)
  • Co-author(s): Morizzi, Julia (Centre for Drug Candidate Optimisation, Parkville, Australia)
    Mannila, Anne (Centre for Drug Candidate Optimisation, Parkville, Australia)
    Ryan, Eileen (Centre for Drug Candidate Optimisation, Parkville, Australia)
    Chiu, Francis (Centre for Drug Candidate Optimisation, Parkville, Australia)
    Creek, Darren (Centre for Drug Candidate Optimisation, Parkville, Australia)
    Shackleford, David (Centre for Drug Candidate Optimisation, Parkville, Australia)
    Charman, Susan (Centre for Drug Candidate Optimisation, Parkville, Australia)
  • Abstract:

    I. Background: 1,2,4-Trioxolanes have recently been shown to be highly effective synthetic antimalarials. One such compound (OZ277/Arterolane) was recently approved for marketing in India in combination with piperaquine (Synriam[TRADEMARK]), and another (OZ439) is currently in Phase II clinical trials.
    II. Aims: The focus of the current work was..

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Last update 4 October 2019

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