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Enhanced dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria using betaine hcl (bhcl)

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: YAGO, Marc Anthony (University of California, San Francisco, Bioengineering and Therapeutic Sciences, San francisco, United States of America)
  • Co-author(s): Frymoyer, Adam (Stanford University, Palo alto, United States of America)
    Smelick, Gillian (Genentech, Inc., South san francisco, United States of America)
    Frassetto, Lynda (University of California, San Francisco, San francisco, United States of America)
    Budha, Nageshwar (Genentech, Inc., South san francisco, United States of America)
    Dresser, Mark (Genentech, Inc., South san francisco, United States of America)
    Ding, Xiao (Genentech, Inc., South san francisco, United States of America)
    Dean, Brian (Genentech, Inc., South san francisco, United States of America)
    Ware, Joseph (Genentech, Inc., South san francisco, United States of America)
    Benet, Leslie (University of California, San Francisco, San francisco, United States of America)
  • Abstract:

    I/II. Background/Aims
    Many orally administered small molecule targeted anti-cancer drugs, such as dasatinib (DAS), exhibit pH-dependent solubility and reduced exposure when given with gastric acid-reducing agents. We have previously shown that a natural supplement, betaine HCl (BHCl), transiently reduced gastric pH in healthy volunteers pretreated ..

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Last update 4 October 2019

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