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Potential modulation on bcrp and mrp 4 by onion: in vivo and ex-vivo studies of onion-methotrexate interaction

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: LIN, Yu-Chin (School of Pharmacy, China Medical University, Taichung, China Taiwan)
  • Co-author(s): Yu, Chung-Ping (School of Pharmacy, China Medical University, Taichung, China Taiwan)
    Chao, Pei-Dawn Lee (School of Pharmacy, China Medical University, Taichung, China Taiwan)
    Hou, Yu-Chi (School of Pharmacy, China Medical University, Taichung, China Taiwan)
    Juang, Shin-Hun (School of Pharmacy, China Medical University, Taichung, China Taiwan)
  • Abstract:

    Ⅰ. Background information:
    Onion (bulb of Allium cepa L.) contains abundant quercetin glycosides. After intake of dry onion powders (DOP), quercetin sulfates/glusuronides were the major molecules in the bloodstream. Methotrexate (MTX), an immunosuppressant with narrow therapeutic window, is a substrate of breast cancer resistance proteins (BCRP)..

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Last update 4 October 2019

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