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Simultaneous determination of erlotinib and its major metabolites in human plasma using an isocratic liquid chromatography tandem mass spectrometry

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: ISHIDA, Takuya (Hamamatsu University School of Medicine, Hospital Pharmacy, Hamamatsu, Japan)
  • Co-author(s): Naito, Takafumi (Hamamatsu University School of Medicine, Hamamatsu, Japan)
    Suda, Takafumi (Hamamatsu University School of Medicine, Hamamatsu, Japan)
    Kawakami, Junichi (Hamamatsu University School of Medicine, Hamamatsu, Japan)
  • Abstract:

    Background: Erlotinib is a selective inhibitor of the epidermal growth factor receptor tyrosine kinase. The relations between the concentrations of its active metabolites, OSI-413 and OSI-420, and clinical response or adverse effect remain unclear. In earlier methods, the concentrations of these metabolites were determined as a total amount.
    Aims: ..

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Last update 4 October 2019

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